Vespignani Land A Clinical Framework
A Clinical Wellness Framework

HEALTHIER Nine principles for the life you're already living

This isn't a prescription. It's a framework — nine letters, each one a door you can walk through at your own pace. Developed across thirty years of clinical practice, taught at Bastyr University, and road-tested on the one patient every doctor eventually has to treat: themselves.

Marco Vespignani, ND
Bastyr Clinical Research Center · Seattle Integrative Medicine · HEAL LLC · Institute for Restorative Health
H

Hydration

A clear glass of water in morning light

Sixty percent of the human body is water. The brain runs closer to 70–75%. Blood: 82–83%. Every chemical reaction in your body depends on pH and water balance. This isn't wellness talk — this is biochemistry.

Clinical Guideline

Aim for 50–100 oz daily. The shorthand: 1 oz per 2 lbs of body weight. Get 8 glasses in before 8 AM and you're ahead of the curve for the rest of the day.

Substitute drinks — tea, coffee, juice — are rewards after your water goals are met, not replacements.

Water quality matters. Tap vs. filtered vs. bottled, container types — these are decisions worth making once and keeping.

Aquaporins — the protein channels that move water across cell membranes — are one of the quietest miracles in human physiology. They don't care about your intentions. They care about supply.

"I believe that water is the only drink for a wise man."

— Henry David Thoreau

8 Before 8

E

Eating Balanced

Fresh chopped vegetables and seeds on an olive wood cutting board

Three macronutrients. Protein and carbohydrates each carry 4 calories per gram. Fat carries 9. That asymmetry shapes every meal whether you're paying attention or not. Aim for 75% of your protein from non-animal sources.

The glycemic index gets all the press, but glycemic load is where the clinical picture lives. A carrot has a high glycemic index but a low glycemic load — because you'd have to eat a bag of them to spike your blood sugar. Context matters.

What to Watch

Essential fatty acids: the omega-3 to omega-6 ratio drives inflammation. Most Western diets are wildly skewed toward omega-6.

Trans fats: avoid at all cost. This is not nuanced advice.

Oxidative stress and antioxidant defense — your cells are in a constant negotiation between damage and repair. Feed the repair side.

Top offenders: high-fructose corn syrup, partially hydrogenated oils, artificial preservatives, synthetic dyes.

Get 10 servings of fruits and vegetables before 10 PM. Eat the colors — the pigments are the medicine. Anthocyanins, carotenoids, flavonoids — nature color-coded the pharmacy.

10 Before 10 · Taste the Rainbow

A

Activity

Running shoes with laces untied on tile floor with towel

The spectrum runs from breathing to Iron Man. Wherever you are on it right now is the right place to start. The minimum effective dose: 20 minutes of continuous aerobic activity, three times a week. Brisk walking is probably the single best exercise most people aren't doing enough of.

Clinical Guideline

Target heart rate: 60–80% of your maximum. The old formula (220 minus your age) gets you close enough to start.

The law of use and disuse: what you use grows stronger. What you neglect atrophies. This applies to muscles, joints, cardiovascular capacity, and — less obviously — your relationship with movement itself.

Stretch. Breathe. Build. Dance. Climb. Use videos, classes, friends, children, pets — whatever gets you moving without making it feel like punishment. The goal isn't performance. The goal is that your body stays a place you want to live in.

In Your Day, Find Time for Play

L

Laughter

Three people laughing together on a picnic blanket at golden hour

Psychoneuroimmunology — PNI — is the study of how your thoughts and emotions directly modulate immune function. Laughter isn't metaphorical medicine. It's actual medicine.

When you laugh: cortisol drops. DHEA rises. Dopamine and serotonin flood the system. Your immune surveillance improves. This isn't folk wisdom — it's measured, published, reproducible biochemistry.

"The most wasted of all days is one without laughter."

— e.e. cummings

Candace Pert's Molecules of Emotion mapped the neuropeptide pathways that connect emotional states to immune function. Laughter yoga exists because someone took the data seriously enough to build a practice around it.

Find Time Each Day to Laugh

T

Thoughts

Weathered leather journal with compass rose, pen, and courage card

Reframe situations in a positive light — not because toxic positivity helps anyone, but because the stories you tell yourself about what's happening become the neurochemical environment your body lives in. The thought precedes the molecule.

Practice

Intentional living. Spirituality — however you define it. Gratitude as a daily practice, not a platitude.

Avoid the monkey mind — the endless recursive loop of worry that solves nothing and costs everything.

The reading list that holds up: How We Choose to Be Happy. Ask and It Is Given (Esther and Jerry Hicks). The Secret — say what you want about the packaging, the core mechanism is sound.

Think with a Hero's Heart

H

Helping Others

Man helping a mother with bags at a NYC taxi, child reaching to help

The spectrum here mirrors Activity: it starts with opening a door for someone and extends all the way to opening your home. Look for opportunities to be of service each day — not as self-improvement theater, but because the research is clear: helping others heals the helper.

Where to Start

Blood donation. Volunteer Match. STEAC. CASA. United Way. Your neighborhood.

Know your strengths and understand how they impact your community. Service that aligns with who you actually are lasts longer than service driven by guilt.

Neighborly Love

I

I Am… (Intention)

Fogged circular mirror with blurred reflection and I AM POWERFUL affirmation

"I am…" — two words that shape everything that follows. Express them daily. Express them when you're in doubt. The declaration isn't magic. But the neuroscience of self-affirmation shows that identity statements prime the brain for congruent action.

Believing is being. Not in a bumper-sticker way — in the way that confidence creates competence creates evidence creates deeper confidence. It's a feedback loop. You have to start it somewhere.

The Inspiration Exercise

Everyone has someone who inspires them. A person real from their life, a character from a book, a historical figure — who is yours? When you think of them, what words come to mind? Think of three. Think of 5 things that are special traits of each. It's ok if you keep using the same words, but try to do different ones that maybe mean the same thing.

Take the Exercise →

Believing Is Being

E

Envision

Person planning at desk with laptop, coffee, and books in morning light

Every letter in HEALTHIER requires forethought. None of this happens by accident. See yourself completing these steps — not as fantasy, but as logistics. Envision is where the framework meets the calendar.

Make It Concrete

Prepare foods the night before. Pack your activity clothes. Make plans for play — don't hope for it.

Make room for others in your schedule. Keep in contact with the people who matter. The phone works in both directions.

Each step in HEALTHIER requires preparation. The ones you prepare for are the ones you do.

Forethought Required

R

Rest · Repeat · Repair

Father and child asleep after bedtime reading, glow-in-the-dark stars on wall

Seven to eight hours. Every night. This is non-negotiable biology, not lifestyle advice. Sleep is when detoxification happens — your five organs of elimination (liver, lungs, skin, GI tract, kidneys) do their heaviest work while you're unconscious.

The 4 R's of GI Repair

Remove — take out the offenders: allergens, irritants, infections.

Replace — restore what's missing: enzymes, acids, bile support.

Re-inoculate — rebuild the microbiome: probiotics, prebiotics, fermented foods.

Repair — heal the lining: L-glutamine, zinc, omega-3s, intestinal support.

Repeat your vision and your steps. Take regular vacations — not as luxury but as maintenance. Reflect. The framework circles back on itself because health is not a destination. It's a practice.

"As long as you are breathing, you are healing."

"Life is like the salmon, swimming upstream against entropy."

Repeat · Reflect · Return

References & Further Reading

Citations loading — see HEALTHIER_CITATIONS.doc for full reference list.